Inter-Method and Inter- Observer Agreement of Retinal Oximetry Image Processing

Retinal tissue hypoperfusion and hypoxia have been implicated in the pathogenesis of vision-threatening disorders such as diabetic retinopathy, [1-4] age-related macular degeneration (AMD), [5,6] glaucoma, [7,8] and vaso-occlusive retinal disease [9-11]. The ability to detect subtle changes in retinal oxygenation and function might be important for early detection, management, and monitoring of these diseases. A complete understanding of the role of oxygen in human retinal pathology has been limited by the lack of non-invasive and sensitive methods for measuring intraretinal oxygen levels.